Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.73 |
| ▸ | HSD17B1 | P14061 | 8/20 | 0.68 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544349 | 0.86 | DYRK1A (0.75) | DYRK1AHSD17B1HSD17B2DYRK1BMAOA | |
| SCHEMBL10170616 | 0.84 | DYRK1A (1.00) | DYRK1AHSD17B1HSD17B2DYRK1BCYP3A4 | |
| SCHEMBL19464560 | 0.83 | HSD17B1 (0.74) | DYRK1AHSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL13486495 | 0.83 | DYRK1A (0.76) | DYRK1AHSD17B10 | |
| SCHEMBL6641942 | 0.83 | DYRK1A (0.74) | DYRK1ACYP2C9CYP2C19 | |
| SCHEMBL31024 | 0.82 | HSD17B1 (0.82) | DYRK1AHSD17B1HSD17B2DYRK1BCYP3A4 | |
| SCHEMBL30522064 | 0.81 | DYRK1A (0.68) | DYRK1AHSD17B1HSD17B2DYRK1BMAOA | |
| SCHEMBL31006 | 0.81 | HSD17B1 (1.00) | DYRK1AHSD17B1HSD17B2DYRK1BMAOA | |
| SCHEMBL14539566 | 0.81 | DYRK1A (0.72) | DYRK1AHSD17B1HSD17B2DYRK1BMAOA | |
| SCHEMBL1259648 | 0.81 | MAOA (0.87) | DYRK1AHSD17B1HSD17B2DYRK1BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273019-A | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as C-Met inhibitors | AVENTIS PHARMA SA (FR) | 2008-09-24 | — | — | CN | disclosed |