Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640089 | 0.81 | PIK3CD (0.41) | KDM4EALDH1A1MAPTTP53DRD2 | |
| SCHEMBL22295995 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1IDH1MAPTTP53 | |
| SCHEMBL17563247 | 0.79 | NPC1 (0.40) | KDM4EALDH1A1MAPTPOLBRECQL | |
| SCHEMBL17563249 | 0.78 | TYR (0.41) | KDM4EALDH1A1TP53DRD2DRD3 | |
| SCHEMBL26006408 | 0.77 | GRIA2 (0.48) | MAPT | |
| SCHEMBL17563245 | 0.76 | ACACB (0.43) | KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL18914245 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1DRD2DRD3APOBEC3A | |
| SCHEMBL21241923 | 0.76 | DRD2 (0.37) | KDM4EALDH1A1IDH1DRD2DRD3 | |
| SCHEMBL21201593 | 0.75 | MAPT (0.61) | MAPTTP53POLB | |
| SCHEMBL13975261 | 0.75 | DRD2 (0.39) | KDM4EALDH1A1IDH1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101287738-B | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| CN-101287738-A | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | CN | disclosed |