SCHEMBL27720358

SCHEMBL27720358

COc1[c]c(OC)ccc1.[NaH]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPK1 P28482 2/20 0.39
CA1 P00915 5/20 0.36
CA2 P00918 5/20 0.36
CA7 P43166 4/20 0.36
CA9 Q16790 4/20 0.36
CA12 O43570 3/20 0.36
CA14 Q9ULX7 3/20 0.36
CA4 P22748 2/20 0.36
CYP3A4 P08684 3/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ACHE P22303 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57641 0.97 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2KDM4EMAPK1CA1
SCHEMBL28053412 0.94 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2KDM4EMAPK1CA1
SCHEMBL27938619 0.94 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2KDM4EMAPK1CA1
SCHEMBL27266457 0.92 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2KDM4EMAPK1CA1
SCHEMBL29160711 0.87 SMN1; SMN2 (0.35) ALDH1A1SMN1; SMN2KDM4EMAPK1CA1
SCHEMBL29242332 0.83 SMN1; SMN2 (0.34) ALDH1A1SMN1; SMN2KDM4EMAPK1
SCHEMBL24442 0.82 CA1 (0.31) ALDH1A1SMN1; SMN2KDM4ECA1CA2
SCHEMBL455316 0.81
SCHEMBL743598 0.81 SMN1; SMN2 (0.38) ALDH1A1SMN1; SMN2KDM4EMAPK1CYP3A4
SCHEMBL159441 0.81 NPSR1 (0.33) ALDH1A1SMN1; SMN2KDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101284778-A Synthetic method of 2, 6-dimethoxy benzoic acid JIANGSU ZHONGDAN GROUP CO LTD (CN) 2008-10-15 CN claimed
CN-105732366-A 3-methoxy-4-chlorobenzoic acid and preparation method thereof 叶芳 2016-07-06 CN disclosed
CN-105712894-A 3-methoxy-4-aminobenzoic acid and preparing method thereof 叶芳 2016-06-29 CN disclosed
CN-101284778-A Synthetic method of 2, 6-dimethoxy benzoic acid JIANGSU ZHONGDAN GROUP CO LTD (CN) 2008-10-15 CN disclosed