SCHEMBL27720508

SCHEMBL27720508

Oc1cc(C(F)(F)F)n(-c2ccccc2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.46
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
CYP1A2 P05177 2/20 0.42
LMNA P02545 1/20 0.42
CYP2C9 P11712 1/20 0.42
HPGD P15428 1/20 0.42
CYP2C19 P33261 1/20 0.42
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
EPHX2 P34913 1/20 0.40
NOTUM Q6P988 1/20 0.40
CSF1R P07333 1/20 0.39
TP53 P04637 1/20 0.38
KDM4E B2RXH2 2/20 0.38
PTGER1 P34995 1/20 0.38
ESR1 P03372 2/20 0.37
ESR2 Q92731 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27944811 0.98 PTGS1 (0.45) PTGS1ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL23401799 0.82 ALDH1A1 (0.64) ALDH1A1CYP1A2CYP2C19
SCHEMBL7570850 0.80 PTGS1 (0.65) PTGS1ALDH1A1MEN1KMT2ACYP1A2
SCHEMBL27925545 0.79 SMN1; SMN2 (0.43) PTGS1ALDH1A1SMN1; SMN2LMNAMAPT
SCHEMBL3281219 0.79 MAPK1 (0.56) PTGS1ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL1012539 0.79 PTGS1 (0.46) PTGS1ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL1981062 0.78 CA1 (0.43) PTGS1ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL3975817 0.78 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2MEN1KMT2ACYP1A2
SCHEMBL10715419 0.77 MAPK1 (0.42) ALDH1A1SMN1; SMN2KMT2ACYP1A2LMNA
SCHEMBL21849180 0.76 GRN (0.56) PTGS1ALDH1A1SMN1; SMN2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103351341-B A kind of organic metal chelate complex and preparation method thereof and application CHIEN-SHIUNG INSTITUTE OF TECHNOLOGY (CN) 2015-09-09 CN disclosed
CN-103351341-A Organic metal chelate, its preparation method and application CHIEN SHIUNG INST TECHNOLOGY 2013-10-16 CN disclosed
CN-101284815-B Pyrazolyloxyacetic acid compounds, preparation method and application NANJING UNIVERSITY OF TECHNOLOGY 2011-04-13 CN disclosed
CN-101284815-A Pyrazolyloxyacetic acid compounds, preparation method and application NANJING UNIVERSITY OF TECHNOLOGY (CN) 2008-10-15 CN disclosed