SCHEMBL3281219

SCHEMBL3281219

Cc1cc(C(F)(F)F)n(-c2ccccc2)n1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.56
CYP1A2 P05177 2/20 0.56
CYP2C19 P33261 1/20 0.56
FCGR1A P12314 1/20 0.54
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
GAA P10253 4/20 0.50
HPGD P15428 3/20 0.50
ALDH1A1 P00352 7/20 0.49
HTT P42858 1/20 0.49
NTRK1 P04629 1/20 0.47
KDM4E B2RXH2 4/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MAPT P10636 1/20 0.46
HSD17B10 Q99714 1/20 0.46
PTGS1 P23219 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2608434 0.84 ALDH1A1 (0.61) MAPK1CYP1A2CYP2C19FCGR1ANPC1
SCHEMBL16202075 0.83 POLB (0.55) CYP1A2CYP2C19GAAHPGDALDH1A1
SCHEMBL24185597 0.83 TP53 (0.50) MAPK1CYP1A2CYP2C19NPC1RAB9A
SCHEMBL597566 0.83 ALDH1A1 (0.45) MAPK1CYP1A2CYP2C19GAAALDH1A1
SCHEMBL31067457 0.82 KMT2A (0.45) MAPK1CYP1A2CYP2C19FCGR1ANPC1
SCHEMBL17064934 0.82 KMT2A (0.45) MAPK1CYP1A2CYP2C19FCGR1ANPC1
SCHEMBL16050150 0.82 MAPK1 (0.56) MAPK1CYP1A2CYP2C19FCGR1ANPC1
SCHEMBL12832342 0.81 POLB (0.42) CYP1A2CYP2C19NPC1RAB9AGAA
SCHEMBL18029568 0.81 MAPK1 (0.54) MAPK1CYP1A2CYP2C19FCGR1ANPC1
SCHEMBL597455 0.80 LMNA (0.60) MAPK1CYP1A2CYP2C19HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242531-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-08-03 US disclosed
WO-2020065614-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 WO disclosed
US-9173400-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-03 US disclosed
US-9113630-B2 Method of controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2015-08-25 US disclosed
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT NEMOURS AND COMPANY (US) 2014-05-22 US disclosed
US-8697734-B2 Method for controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2014-04-15 US disclosed
US-8637552-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-28 US disclosed
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2013-01-31 US disclosed
US-20060079561-A1 Insecticidal anthranilamides FMC CORPORATION 2006-04-13 US disclosed
US-6995178-B2 Insecticidal anthranilamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-02-07 US disclosed
CN-1713819-A Anthranilamide arthropodicide treatment DU PONT (US) 2005-12-28 CN disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 US disclosed
CN-1541063-A Method for controlling particular insects by applying anthranilamide compounds ��Ļ���Ű˾ 2004-10-27 CN disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 US disclosed
US-20040142984-A1 Insecticidal anthranilamides FMC CORPORATION 2004-07-22 US disclosed
US-6747047-B2 ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY 2004-06-08 US disclosed
US-20030229050-A1 Insecticidal anthranilamides FMC CORPORATION 2003-12-11 US disclosed
CN-1419537-A Insecticidal anthranilamides DU PONT (US) 2003-05-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242531-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP MAPK1 4069/4885CYP1A2 767/4885CYP2C19 561/4885
US-20140140973-A1 METHOD OF CONTROLLING PARTICULAR INSECT PESTS BY APPLYNG ANTHRANILAMIDE COMPOUNDS ANTXR2, NIT2, TDO2 MAPK1 2686/4885CYP1A2 153/4885CYP2C19 912/4885
US-20130031677-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 MAPK1 400/4885CYP1A2 639/4885CYP2C19 2221/4885
US-20040142984-A1 Insecticidal anthranilamides ANTXR2, NIT2, AKR7A2 MAPK1 1213/4885CYP1A2 15/4885CYP2C19 885/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 MAPK1 151/4885CYP1A2 455/4885CYP2C19 2492/4885
US-20060079561-A1 Insecticidal anthranilamides ANTXR2, CYB5R3, NIT2 MAPK1 1311/4885CYP1A2 8/4885CYP2C19 272/4885
US-20030229050-A1 Insecticidal anthranilamides ANTXR2, NIT2, CYB5R3 MAPK1 1291/4885CYP1A2 10/4885CYP2C19 639/4885
US-20130028879-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS ANTXR2, CYP4X1, PRDX1 MAPK1 2641/4885CYP1A2 170/4885CYP2C19 377/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 MAPK1 1809/4885CYP1A2 324/4885CYP2C19 1030/4885
US-20140141972-A1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT ANTXR2, ARF5, NPR1 MAPK1 400/4885CYP1A2 639/4885CYP2C19 2221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.