Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773781 | 0.93 | NR1H4 (0.45) | NR1H4MRGPRX4NR4A2PTPN11RXRA | |
| SCHEMBL2773617 | 0.89 | NR1H4 (0.47) | NR1H4MRGPRX4NR4A2 | |
| SCHEMBL2772558 | 0.88 | NR1H4 (0.47) | NR1H4MRGPRX4NR4A2RXRARXRB | |
| SCHEMBL2772065 | 0.85 | NR1H4 (0.46) | NR1H4MRGPRX4NR4A2RXRARXRB | |
| SCHEMBL2772063 | 0.84 | PPARA (0.43) | NR1H4MRGPRX4NR4A2RXRARXRB | |
| SCHEMBL2774437 | 0.83 | NR1H4 (0.50) | NR1H4MRGPRX4NR4A2RXRARXRB | |
| SCHEMBL2771298 | 0.81 | NR1H4 (0.60) | NR1H4 | |
| SCHEMBL2775206 | 0.81 | MRGPRX4 (0.48) | NR1H4MRGPRX4 | |
| SCHEMBL2771295 | 0.81 | NR1H4 (0.60) | NR1H4 | |
| SCHEMBL3150343 | 0.80 | NR1H4 (0.51) | NR1H4MRGPRX4NR4A2PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |