Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 5/20 | 0.36 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28769706 | 0.94 | KCNH2 (0.42) | KCNH2NR3C1MGLLBIRC5HDAC3 | |
| SCHEMBL4283107 | 0.84 | KCNH2 (0.52) | KCNH2NR3C1MGLLBIRC5 | |
| SCHEMBL27724676 | 0.82 | NR3C1 (0.58) | NR3C1 | |
| SCHEMBL4285257 | 0.82 | KCNH2 (0.49) | KCNH2NR3C1EPHX2MGLLBIRC5 | |
| SCHEMBL27704110 | 0.78 | NR3C1 (0.38) | KCNH2NR3C1 | |
| SCHEMBL4278445 | 0.78 | NR3C1 (0.43) | KCNH2NR3C1MGLLBIRC5HDAC3 | |
| SCHEMBL28773308 | 0.76 | KCNH2 (0.47) | KCNH2MGLLBIRC5HDAC3HDAC4 | |
| SCHEMBL27704097 | 0.75 | NR3C1 (0.50) | NR3C1 | |
| SCHEMBL27724544 | 0.74 | NR3C1 (0.47) | NR3C1 | |
| SCHEMBL27724663 | 0.74 | NR3C1 (0.53) | NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101193869-A | Glucocortioid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-06-04 | — | — | CN | claimed |