Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772895 | 0.86 | POLB (0.55) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL2772621 | 0.84 | TP53 (0.63) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL30128312 | 0.82 | ALDH1A1 (0.71) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL2772888 | 0.81 | POLB (0.54) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL2772911 | 0.80 | NPC1 (0.65) | SMN1; SMN2ALDH1A1MAPTKMT2AHCRTR1 | |
| SCHEMBL30300541 | 0.80 | POLB (0.62) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL3772178 | 0.79 | POLB (0.76) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL2246120 | 0.78 | POLB (0.75) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL7076037 | 0.78 | RAB9A (0.61) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL31741395 | 0.77 | POLB (0.58) | POLBHTR2CHTR2BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | claimed |
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |