Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 15/20 | 0.55 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31147950 | 0.86 | F10 (0.42) | F10KLKB1TSHRRORCKDM1A | |
| SCHEMBL1999384 | 0.84 | F10 (0.51) | F10KLKB1F2 | |
| SCHEMBL4690430 | 0.77 | F10 (0.47) | F10KLKB1 | |
| SCHEMBL29836179 | 0.73 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL3967997 | 0.73 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL12956033 | 0.72 | F10 (0.47) | F10KLKB1 | |
| SCHEMBL661699 | 0.72 | TAAR1 (0.51) | — | |
| SCHEMBL30874634 | 0.72 | TAAR1 (0.51) | — | |
| SCHEMBL27729135 | 0.72 | F10 (0.45) | F10KLKB1 | |
| SCHEMBL1922818 | 0.71 | ALDH1A1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102617567-A | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB CO | 2012-08-01 | — | — | CN | disclosed |
| CN-101357914-A | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-02-04 | — | — | CN | disclosed |