Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874634 | 1.00 | TAAR1 (0.51) | TAAR1ALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL27592315 | 0.98 | TAAR1 (0.50) | TAAR1ALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1554320 | 0.86 | KDM4E (0.53) | ALDH1A1SMN1; SMN2TDP1L3MBTL1LMNA | |
| SCHEMBL506923 | 0.85 | SMN1; SMN2 (0.46) | TAAR1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL16396591 | 0.84 | ANO1 (0.47) | TAAR1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL16112668 | 0.84 | P2RX7 (0.45) | TAAR1ALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL7637943 | 0.81 | ALDH1A1 (0.47) | TAAR1ALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL513027 | 0.81 | L3MBTL1 (0.60) | TAAR1ALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL31053374 | 0.81 | L3MBTL1 (0.60) | TAAR1ALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1444146 | 0.81 | TAAR1 (0.50) | TAAR1ALDH1A1SMN1; SMN2TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117164593-A | Pyrimidoindoles compound, preparation method and application thereof, and anti-erythroleukemia drug | 贵州省天然产物研究中心 | 2023-12-05 | — | — | CN | claimed |
| US-12612413-B2 | Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2026-04-28 | — | — | US | disclosed |
| EP-4724435-A1 | BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| EP-4371986-B1 | SUBSTITUTED PYRIDAZINONES AS HERBICIDES | SYNGENTA CROP PROTECTION AG (CH) | 2026-02-25 | — | — | EP | disclosed |
| US-12540128-B2 | Substituted pyridazinones as herbicides | SYNGENTA CROP PROTECTION AG (CH) | 2026-02-03 | — | — | US | disclosed |
| US-12540120-B2 | Herbicidal compounds | SYNGENTA CROP PROTECTION AG (CH) | 2026-02-03 | — | — | US | disclosed |
| US-20250302803-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2025-10-02 | — | — | US | disclosed |
| US-12357610-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | UNIVERSITY OF HOUSTON SYSTEM (US) | 2025-07-15 | — | — | US | disclosed |
| US-20250051344-A1 | BIFUNCTIONAL SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. | 2025-02-13 | — | — | US | disclosed |
| WO-2024254532-A1 | BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| US-6013652-A | ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIHISTAMINES | MERCK & CO., INC. (US) | 2000-01-11 | — | — | US | disclosed |
| US-5977116-A | Piperazine, piperidine and tetrahydropyridine derivatives | MERCK SHARP & DOHME LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5962462-A | COMPOUNDS WHICH INHIBIT THE ENTRY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INTO TARGET CELLS; DELAYING THE ONSET OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). | MERCK & CO., INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0863895-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-16 | — | — | EP | disclosed |
| WO-1998025605-A1 | SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |
| WO-1997018203-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-22 | — | — | WO | disclosed |
| EP-0702681-A1 | SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS | MERCK & CO. INC. (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029309-A1 | SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1994-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612413-B2 | Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same | CASP6, CASP3, BAX | TAAR1 1089/4885ALDH1A1 4013/4885SMN1; SMN2 565/4885 |
| US-12540128-B2 | Substituted pyridazinones as herbicides | CBR3, CBR1, CNPY2 | TAAR1 1031/4885ALDH1A1 183/4885SMN1; SMN2 4666/4885 |
| US-12357610-B2 | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures | AADAC, GABRB2, GABARAPL2 | TAAR1 3022/4885ALDH1A1 158/4885SMN1; SMN2 995/4885 |
| US-12540120-B2 | Herbicidal compounds | CBR3, CBR1, HACL2 | TAAR1 1374/4885ALDH1A1 137/4885SMN1; SMN2 4517/4885 |
| US-20250302803-A1 | ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES | AADAC, GABRB2, GABARAPL2 | TAAR1 3022/4885ALDH1A1 158/4885SMN1; SMN2 995/4885 |
| US-20250051344-A1 | BIFUNCTIONAL SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF | SMARCA2, SMARCE1, SMARCB1 | TAAR1 3786/4885ALDH1A1 3865/4885SMN1; SMN2 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.