Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 10/20 | 0.38 |
| ▸ | HTR7 | P34969 | 9/20 | 0.38 |
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767333 | 0.82 | TP53 (0.42) | SMN1; SMN2TP53CHRNA7HTR3A | |
| SCHEMBL2772968 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53CHRNA7HTR3ARECQL | |
| SCHEMBL2767531 | 0.76 | TP53 (0.42) | SMN1; SMN2TP53HTR2AHTR7CHRNA7 | |
| SCHEMBL2787494 | 0.72 | TP53 (0.40) | SMN1; SMN2TP53 | |
| SCHEMBL2440386 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2TP53HTR2AHTR7DRD2 | |
| SCHEMBL2786903 | 0.69 | EPHX2 (0.39) | SMN1; SMN2RECQL | |
| SCHEMBL2441536 | 0.68 | TP53 (0.64) | SMN1; SMN2TP53CHRNA7HTR3A | |
| SCHEMBL2769745 | 0.67 | RAB9A (0.43) | SMN1; SMN2RECQL | |
| SCHEMBL2440614 | 0.66 | TP53 (0.52) | SMN1; SMN2TP53HTR2AHTR7DRD2 | |
| SCHEMBL11422384 | 0.66 | LMNA (0.37) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | claimed |
| US-7696238-B2 | Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics | GRUENENTHAL GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | KCNQ1, KCNQ2, KCNQ3 | SMN1; SMN2 1349/4885TP53 4784/4885HTR2A 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.