Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30863327 | 0.89 | VCAM1 (0.66) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6405571 | 0.86 | VCAM1 (0.54) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL13011426 | 0.85 | VCAM1 (0.53) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2772166 | 0.85 | TSHR (0.65) | LMNAMEN1KMT2AALDH1A1CES2 | |
| SCHEMBL2484847 | 0.83 | VCAM1 (0.57) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL13635141 | 0.83 | VCAM1 (0.51) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL3775502 | 0.83 | ERN1 (0.54) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL13011190 | 0.83 | VCAM1 (0.51) | VCAM1MEN1KMT2AALDH1A1RXFP1 | |
| SCHEMBL13011439 | 0.83 | VCAM1 (0.51) | VCAM1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL410258 | 0.82 | PDK2 (0.51) | ALDH1A1HPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193125-B1 | OXADIAZOLE DERIVATIVES | MERCK SERONO SA (CH) | 2017-01-11 | — | — | EP | disclosed |
| EP-2193126-B1 | OXADIAZOLE DIARYL COMPOUNDS | MERCK SERONO SA (CH) | 2015-06-24 | — | — | EP | disclosed |
| EP-2193126-B1 | OXADIAZOLE DIARYL COMPOUNDS | MERCK SERONO SA (CH) | 2015-06-24 | — | — | EP | disclosed |
| US-8889668-B2 | Oxadiazole diaryl compounds | MERCK SERONO SA (CH) | 2014-11-18 | — | — | US | disclosed |
| US-8889668-B2 | Oxadiazole diaryl compounds | MERCK SERONO SA (CH) | 2014-11-18 | — | — | US | disclosed |
| US-8889668-B2 | Oxadiazole diaryl compounds | MERCK SERONO SA (CH) | 2014-11-18 | — | — | US | disclosed |
| US-20130109676-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA (CH) | 2013-05-02 | — | — | US | disclosed |
| US-20130109676-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA (CH) | 2013-05-02 | — | — | US | disclosed |
| US-20130109676-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA (CH) | 2013-05-02 | — | — | US | disclosed |
| US-8404676-B2 | Oxadiazole diaryl compounds | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | disclosed |
| US-8202865-B2 | Oxadiazole derivatives | MERCK SERONO SA (CH) | 2012-06-19 | — | — | US | disclosed |
| US-20100305104-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA | 2010-12-02 | — | — | US | disclosed |
| US-20100305104-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA | 2010-12-02 | — | — | US | disclosed |
| US-20100305104-A1 | Oxadiazole Diaryl Compounds | MERCK SERONO SA | 2010-12-02 | — | — | US | disclosed |
| US-20100240658-A1 | Oxadiazole Derivatives | MERCK SERONO SA (CH) | 2010-09-23 | — | — | US | disclosed |
| EP-2193126-A1 | OXADIAZOLE DIARYL COMPOUNDS | Merck Serono S.A. (CH) | 2010-06-09 | — | — | EP | disclosed |
| EP-2193125-A2 | OXADIAZOLE DERIVATIVES | Merck Serono S.A. (CH) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009043890-A1 | OXADIAZOLE DIARYL COMPOUNDS | MERCK SERONO S.A. (CH) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009043890-A1 | OXADIAZOLE DIARYL COMPOUNDS | MERCK SERONO S.A. (CH) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009043889-A2 | OXADIAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305104-A1 | Oxadiazole Diaryl Compounds | OXA1L, RO60, SSB | VCAM1 1211/4885LMNA 4666/4885MEN1 955/4885 |
| US-20100240658-A1 | Oxadiazole Derivatives | OXA1L, RO60, NQO2 | VCAM1 1051/4885LMNA 4578/4885MEN1 1660/4885 |
| US-20130109676-A1 | Oxadiazole Diaryl Compounds | OXA1L, RO60, SSB | VCAM1 797/4885LMNA 4667/4885MEN1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.