Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776641 | 0.93 | NOTUM (0.54) | NOTUMPDK2S1PR1P4HBRBP4 | |
| SCHEMBL320542 | 0.85 | NOTUM (0.54) | NOTUMPDK2S1PR1P4HBRBP4 | |
| SCHEMBL536257 | 0.81 | NOTUM (0.55) | NOTUMPDK2P4HBRBP4MEN1 | |
| SCHEMBL10907300 | 0.79 | NOTUM (0.66) | NOTUMPDK2P4HBMEN1MAPT | |
| SCHEMBL205089 | 0.79 | NOTUM (0.60) | NOTUMMEN1MAPTKMT2ANPC1 | |
| SCHEMBL10035005 | 0.79 | NOTUM (0.52) | NOTUMPDK2RBP4MAPTKMT2A | |
| SCHEMBL536555 | 0.79 | NOTUM (0.52) | NOTUMPDK2P4HBRBP4AKR1C3 | |
| SCHEMBL10035257 | 0.78 | NOTUM (0.52) | NOTUMPDK2P4HBRBP4AKR1C3 | |
| SCHEMBL319915 | 0.78 | RORC (0.52) | PDK2S1PR1KMT2ATRPV1AKR1C3 | |
| SCHEMBL14925368 | 0.78 | PDK2 (0.50) | PDK2S1PR1NPSR1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193125-A2 | OXADIAZOLE DERIVATIVES | Merck Serono S.A. (CH) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009043889-A2 | OXADIAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2009-04-09 | — | — | WO | disclosed |