Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16024176 | 0.89 | POLB (0.45) | POLBSLC6A2SLC6A4SLC6A3CASR | |
| SCHEMBL28110010 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3L3MBTL1ALDH1A1 | |
| SCHEMBL7353471 | 0.81 | EED (0.52) | POLBSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL16320729 | 0.81 | AOC3 (0.46) | POLBSLC6A2SLC6A4SLC6A3CASR | |
| SCHEMBL28787874 | 0.81 | AOC3 (0.54) | POLBSLC6A2SLC6A4SLC6A3AOC3 | |
| SCHEMBL28167366 | 0.77 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3L3MBTL1ALDH1A1 | |
| SCHEMBL13572926 | 0.77 | CHRM2 (0.52) | SLC6A2SLC6A4SLC6A3L3MBTL1MEN1 | |
| SCHEMBL28110549 | 0.77 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3L3MBTL1ALDH1A1 | |
| SCHEMBL23923970 | 0.77 | BCHE (0.53) | FFAR1MEN1KMT2A | |
| SCHEMBL30317816 | 0.77 | BCHE (0.53) | FFAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101238124-A | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease | MERCK & CO INC (US) | 2008-08-06 | — | — | CN | disclosed |