Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27731011 | 0.87 | HTT (0.47) | HTTMAP4K4PIM1PIM3AURKB | |
| SCHEMBL27731002 | 0.80 | SIRT2 (0.45) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL27710539 | 0.76 | HTT (0.59) | HTTSIRT2KDM4ENPC1RAB9A | |
| SCHEMBL27940845 | 0.75 | PARP1 (0.58) | KDM4ENPC1TP53RECQLRAB9A | |
| SCHEMBL28741252 | 0.74 | GAA (0.46) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL18293491 | 0.72 | TAAR1 (0.48) | KDM4ERECQLSMN1; SMN2PLA2G2ATSHR | |
| SCHEMBL27730996 | 0.72 | KAT6A (0.46) | HTTDYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL27730967 | 0.71 | MEN1 (0.46) | SIRT2TSHRTDP1L3MBTL1 | |
| SCHEMBL27940776 | 0.70 | PARP1 (0.53) | MAP4K4PIM1RPS6KB1CSNK2A1AURKB | |
| SCHEMBL28025564 | 0.69 | RXRA (0.51) | HTTKDM4ETP53SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | claimed |
| CN-101186586-B | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY | 2010-06-30 | — | — | CN | disclosed |
| CN-101186586-A | N,N'-difluorophenyl derivative of 4-methoxyl-1,3-phthalamide and use thereof | UNIV TIANJIN TECHNOLOGY (CN) | 2008-05-28 | — | — | CN | disclosed |