Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27733157 | 0.87 | KMT2A (0.34) | KDM4ECHEK1KMT2AMEN1ADRB2 | |
| SCHEMBL27753566 | 0.85 | PARP1 (0.35) | HDAC3HDAC1HDAC2HDAC8ADRB2 | |
| SCHEMBL27760136 | 0.82 | PTPN1 (0.40) | ALDH1A1KMT2AMEN1ADRB2DRD2 | |
| SCHEMBL2933529 | 0.82 | KDM4E (0.47) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27758463 | 0.81 | MPO (0.37) | KMT2AMEN1ADRB2ADRB1DRD2 | |
| SCHEMBL3209496 | 0.80 | PTPN1 (0.48) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27745950 | 0.80 | PTPN1 (0.39) | KMT2AMEN1ADRB2MPOSMN1; SMN2 | |
| SCHEMBL27733144 | 0.77 | IDH1 (0.40) | MPO | |
| SCHEMBL27733141 | 0.74 | KAT8 (0.36) | KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4557176 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1KMT2AMEN1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101321743-A | 1,1, 3-trioxo-1, 2, 5-thiadiazolidines as PTP-enzyme inhibitors and their use | NOVARTIS AG (CH) | 2008-12-10 | — | — | CN | claimed |
| CN-101883579-A | Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders | NOVARTIS AG | 2010-11-10 | — | — | CN | disclosed |
| CN-101547694-A | Protein tyrosine phosphatase inhibitors for promoting physiological cardiac hypertrophy | NOVARTIS AG (CH) | 2009-09-30 | — | — | CN | disclosed |
| CN-101321743-A | 1,1, 3-trioxo-1, 2, 5-thiadiazolidines as PTP-enzyme inhibitors and their use | NOVARTIS AG (CH) | 2008-12-10 | — | — | CN | disclosed |