Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.34 |
| ▸ | MPO | P05164 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | SOX18 | P35713 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27758463 | 0.90 | MPO (0.37) | PTPN1MEN1KMT2AABCB1MPO | |
| SCHEMBL27760075 | 0.87 | PTPN1 (0.48) | PTPN1KMT2ATP53CYP3A4ALOX15 | |
| SCHEMBL27745955 | 0.87 | PTPN1 (0.46) | PTPN1MEN1KMT2ANR1H3 | |
| SCHEMBL27745954 | 0.84 | PTPN1 (0.38) | PTPN1 | |
| SCHEMBL27745951 | 0.83 | PTPN1 (0.35) | PTPN1SOX18ALOX15ADRB2 | |
| SCHEMBL27760136 | 0.82 | PTPN1 (0.40) | PTPN1MEN1KMT2AMPOADRB2 | |
| SCHEMBL27725129 | 0.81 | PTPN1 (0.40) | PTPN1 | |
| SCHEMBL27745946 | 0.81 | PTPN1 (0.36) | PTPN1 | |
| SCHEMBL27725116 | 0.81 | PTPN1 (0.37) | PTPN1 | |
| SCHEMBL630068 | 0.80 | PTPN1 (0.64) | PTPN1MEN1KMT2AABCB1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101326173-A | Thiadiazoles derivant as anti-diabetes agent | NOVARTIS AG (CH) | 2008-12-17 | — | — | CN | claimed |
| CN-101883579-A | Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders | NOVARTIS AG | 2010-11-10 | — | — | CN | disclosed |
| CN-101547694-A | Protein tyrosine phosphatase inhibitors for promoting physiological cardiac hypertrophy | NOVARTIS AG (CH) | 2009-09-30 | — | — | CN | disclosed |
| CN-101326173-A | Thiadiazoles derivant as anti-diabetes agent | NOVARTIS AG (CH) | 2008-12-17 | — | — | CN | disclosed |