Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | SCN4A | P35499 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292606 | 0.81 | KMT2A (0.41) | MEN1KMT2AKDM4EALDH1A1SCN4A | |
| SCHEMBL941531 | 0.79 | KMT2A (0.45) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3355925 | 0.77 | MEN1 (0.45) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL262332 | 0.77 | MEN1 (0.41) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL1045003 | 0.76 | TSHR (0.36) | MEN1KMT2AALDH1A1 | |
| SCHEMBL27458128 | 0.76 | KMT2A (0.50) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6716155 | 0.76 | KMT2A (0.42) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8417929 | 0.74 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3182203 | 0.74 | KMT2A (0.53) | MEN1KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5591734 | 0.74 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389613-B | Macrocyclic factor viia inhibitors useful as anticoagulants | BRISTOL MYERS SQUIBB CO | 2011-10-12 | — | — | CN | disclosed |
| CN-101389613-A | Macrocyclic factor viia inhibitors useful as anticoagulants | BRISTOL MYERS SQUIBB CO (US) | 2009-03-18 | — | — | CN | disclosed |