Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13964533 | 0.91 | LMNA (0.43) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL472102 | 0.83 | PTGS1 (0.38) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8161008 | 0.83 | POLB (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8555930 | 0.83 | MEN1 (0.44) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL12299699 | 0.80 | PTGS1 (0.36) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13683282 | 0.80 | MEN1 (0.44) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL14394607 | 0.80 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29034429 | 0.79 | MEN1 (0.48) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL5086988 | 0.79 | MAPT (0.47) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL42433 | 0.79 | LMNA (0.45) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101522645-B | Phenyl derivatives and their use as immunomodulators | ACTELION PHARMACEUTICALS LTD | 2013-01-09 | — | — | CN | disclosed |
| CN-101528726-B | Thiophene derivatives as S1P1/EDG1 receptor agonists | ACTELION PHARMACEUTICALS LTD | 2012-11-14 | — | — | CN | disclosed |
| EP-2069322-B1 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| EP-2069318-B1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| US-8133910-B2 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-03-13 | — | — | US | disclosed |
| US-8044076-B2 | Phenyl derivatives and their use as immunomodulators | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-10-25 | — | — | US | disclosed |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-04-08 | — | — | US | disclosed |
| US-20100048648-A1 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-02-25 | — | — | US | disclosed |
| CN-101528726-A | Thiophene derivatives as S1P1/EDG1 receptor agonists | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-09 | — | — | CN | disclosed |
| CN-101522645-A | Phenyl derivatives and their use as immunomodulators | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-02 | — | — | CN | disclosed |
| EP-2069322-A2 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-17 | — | — | EP | disclosed |
| EP-2069318-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-17 | — | — | EP | disclosed |
| US-7479531-B2 | Copolymer of ethylene and/or propylene; and octen-1-ol,7-octen-1-ol trimethylsilyl ether, octenyl acetate, 5-norbornen-2-yl acetate, 5-norbornen-2-ol and/or 5-norbornen-2-ol trimethylsilyl ether; transition metal catalyst comprising 2-arylazo- or 2-arylphosphazo- phenoxide ligand | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2009-01-20 | — | — | US | disclosed |
| WO-2008035239-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008029306-A2 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-13 | — | — | WO | disclosed |
| US-7285609-B2 | Olefin polymerization catalyst system useful for polar monomers | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-23 | — | — | US | disclosed |
| US-7285609-B2 | Olefin polymerization catalyst system useful for polar monomers | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-23 | — | — | US | disclosed |
| EP-1626976-B1 | OLEFIN POLYMERIZATION CATALYST SYSTEM | EXXONMOBIL CHEM PATENTS INC (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20070197751-A1 | Olefin polymerization catalyst system useful for polar monomers | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197751-A1 | Olefin polymerization catalyst system useful for polar monomers | EXXONMOBIL CHEMICAL PATENTS INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048648-A1 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | S1PR1, S1PR3, S1PR2 | MEN1 1296/4885KMT2A 3320/4885ALDH1A1 2911/4885 |
| US-20100087495-A1 | PHENYL DERIVATIVES AND THEIR USE AS IMMUNOMODULATORS | IL2, CD47, CD74 | MEN1 4441/4885KMT2A 2793/4885ALDH1A1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.