Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LIFR | P42702 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770887 | 0.94 | NR1H4 (0.56) | NR1H4MRGPRX4KDM4C | |
| SCHEMBL2772217 | 0.91 | NR1H4 (0.57) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2773887 | 0.90 | NR1H4 (0.61) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2773436 | 0.90 | NR1H4 (0.55) | NR1H4MRGPRX4NPC1NR4A2RAB9A | |
| SCHEMBL2771708 | 0.89 | NR1H4 (0.54) | NR1H4MRGPRX4 | |
| SCHEMBL2772748 | 0.89 | NR1H4 (0.54) | NR1H4MRGPRX4NR4A2KDM4C | |
| SCHEMBL4035936 | 0.89 | NR1H4 (0.53) | NR1H4MRGPRX4 | |
| SCHEMBL2771437 | 0.88 | NR1H4 (0.58) | NR1H4MRGPRX4 | |
| SCHEMBL2771137 | 0.88 | NR1H4 (0.52) | NR1H4MRGPRX4KDM4C | |
| SCHEMBL2773716 | 0.87 | NR1H4 (0.52) | NR1H4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |