Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773371 | 0.89 | NR1H4 (0.58) | NR1H4MRGPRX4 | |
| SCHEMBL2770887 | 0.87 | NR1H4 (0.56) | NR1H4MRGPRX4PPARG | |
| SCHEMBL2772217 | 0.86 | NR1H4 (0.57) | NR1H4MRGPRX4 | |
| SCHEMBL2773887 | 0.85 | NR1H4 (0.61) | NR1H4MRGPRX4 | |
| SCHEMBL2773436 | 0.85 | NR1H4 (0.55) | NR1H4MRGPRX4 | |
| SCHEMBL2771708 | 0.84 | NR1H4 (0.54) | NR1H4MRGPRX4 | |
| SCHEMBL2772748 | 0.84 | NR1H4 (0.54) | NR1H4MRGPRX4 | |
| SCHEMBL2772620 | 0.83 | NR1H4 (0.58) | NR1H4MRGPRX4 | |
| SCHEMBL2771137 | 0.83 | NR1H4 (0.52) | NR1H4MRGPRX4 | |
| SCHEMBL2773716 | 0.83 | NR1H4 (0.52) | NR1H4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140183-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |