SCHEMBL27734845

SCHEMBL27734845

COc1ccc(CNc2cc(C)cc(C)c2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.66
LMNA P02545 3/20 0.66
NPC1 O15118 3/20 0.66
RAB9A P51151 3/20 0.66
POLB P06746 2/20 0.66
L3MBTL1 Q9Y468 2/20 0.66
ALOX12 P18054 2/20 0.61
GAA P10253 2/20 0.60
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
ALDH1A1 P00352 3/20 0.57
KDM4E B2RXH2 2/20 0.57
TDP1 Q9NUW8 1/20 0.57
TUBB4A P04350 1/20 0.53
TUBB P07437 1/20 0.53
TUBA3C P0DPH7 1/20 0.53
TUBA1B P68363 1/20 0.53
TUBA4A P68366 1/20 0.53
TUBB4B P68371 1/20 0.53
TUBB3 Q13509 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28798880 0.93 NPC1 (0.62) MAPTLMNANPC1RAB9APOLB
SCHEMBL21722571 0.85 MAPT (0.65) MAPTLMNANPC1RAB9APOLB
SCHEMBL169696 0.84 MAPT (0.72) MAPTLMNANPC1RAB9APOLB
SCHEMBL8345852 0.84 MAPT (0.72) MAPTLMNANPC1RAB9APOLB
SCHEMBL10055019 0.83 MAPT (0.82) MAPTLMNANPC1RAB9AL3MBTL1
SCHEMBL5669873 0.83 MAPT (0.82) MAPTLMNANPC1RAB9AL3MBTL1
SCHEMBL1844199 0.83 MAPT (0.82) MAPTLMNANPC1RAB9AL3MBTL1
SCHEMBL20411802 0.81 HTT (0.54) MAPTLMNANPC1RAB9APOLB
SCHEMBL10267340 0.80 MAPT (0.68) MAPTLMNANPC1RAB9AL3MBTL1
SCHEMBL9190510 0.79 TUBB4A (0.77) MAPTLMNANPC1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101243146-B Coating composition ALTANA ELEC INSULATION GMBH 2012-01-11 CN claimed
CN-101243146-A Coating composition ALTANA ELEC INSULATION GMBH (DE) 2008-08-13 CN claimed
CN-101243146-B Coating composition ALTANA ELEC INSULATION GMBH 2012-01-11 CN disclosed
CN-102051106-A Coating composition for protecting electronic components and circuit boards DONGGUAN JIANXIN ELECTRONIC MATERIAL CO LTD 2011-05-11 CN disclosed
CN-101243146-A Coating composition ALTANA ELEC INSULATION GMBH (DE) 2008-08-13 CN disclosed