Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27734882 | 0.83 | PTGS2 (0.35) | PTGDR2AKR1C3CYP11B1CYP11B2PTGS2 | |
| SCHEMBL27714461 | 0.83 | PTGS2 (0.35) | PTGDR2PTGS2PTGS1CYP2C9AKR1B1 | |
| SCHEMBL27734880 | 0.82 | PTGDR2 (0.41) | PTGDR2AKR1C3CYP11B1CYP11B2PTGS2 | |
| SCHEMBL2773692 | 0.80 | PTGDR2 (0.58) | PTGDR2AKR1C3PTGS2PTGS1CYP2C9 | |
| SCHEMBL2770081 | 0.79 | PTGDR2 (0.46) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL27714354 | 0.71 | PTGS2 (0.33) | PTGDR2PTGS2PTGS1CYP2C9AKR1B1 | |
| SCHEMBL27734984 | 0.70 | PTGDR2 (0.55) | PTGDR2PTGS2PTGS1CYP2C9AKR1B1 | |
| SCHEMBL27714352 | 0.70 | PTGDR2 (0.35) | PTGDR2PTGS2CYP2C9AKR1B1 | |
| SCHEMBL27714375 | 0.69 | PTGDR2 (0.35) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL27714373 | 0.68 | PTGDR2 (0.38) | PTGDR2PTGS2PTGS1CYP2C9AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243086-A | Indolizine derivatives and their use as CRTH2 antagonists | ARGENTA DISCOVERY LTD (GB) | 2008-08-13 | — | — | CN | disclosed |