Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27714352 | 0.86 | PTGDR2 (0.35) | PTGDR2PTGS2CYP2C9AKR1B1CYP1A2 | |
| SCHEMBL2770081 | 0.84 | PTGDR2 (0.46) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL27714373 | 0.84 | PTGDR2 (0.38) | PTGDR2PTGS2CYP2C9AKR1B1CYP1A2 | |
| SCHEMBL2773692 | 0.84 | PTGDR2 (0.58) | PTGDR2PTGS2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL27734876 | 0.82 | PTGDR2 (0.36) | PTGDR2PTGS2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL27734882 | 0.81 | PTGS2 (0.35) | PTGDR2PTGS2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL27734885 | 0.79 | PTGDR2 (0.46) | PTGDR2MEN1KMT2AGAA | |
| SCHEMBL27734984 | 0.78 | PTGDR2 (0.55) | PTGDR2PTGS2CYP2C9AKR1B1CYP1A2 | |
| SCHEMBL27735049 | 0.74 | PTGDR2 (0.60) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL27735074 | 0.74 | PTGDR2 (0.45) | PTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243086-A | Indolizine derivatives and their use as CRTH2 antagonists | ARGENTA DISCOVERY LTD (GB) | 2008-08-13 | — | — | CN | disclosed |