Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.68 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773518 | 0.84 | KMT2A (0.61) | KMT2ADUSP3PTPN11MAPTMEN1 | |
| SCHEMBL5866924 | 0.77 | LMNA (0.79) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL13742187 | 0.77 | HCRTR1 (0.51) | KMT2ADUSP3PTPN11MAPTMEN1 | |
| SCHEMBL13742243 | 0.75 | MAPT (0.51) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL21357031 | 0.75 | NPC1 (0.74) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL16697971 | 0.75 | KMT2A (0.59) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL2772621 | 0.74 | TP53 (0.63) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL2774749 | 0.74 | RAB9A (0.87) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL195970 | 0.74 | SMN1; SMN2 (0.78) | KMT2AMAPTMEN1RAB9APOLB | |
| SCHEMBL2775857 | 0.73 | LMNA (0.68) | KMT2AMAPTMEN1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | claimed |
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |