Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | GCK | P35557 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30419382 | 0.79 | MAPT (0.47) | RAB9ANPC1GCKKMT2AGFER | |
| SCHEMBL22005509 | 0.76 | MAPK1 (0.54) | RAB9ANPC1TSHRKMT2AGFER | |
| SCHEMBL129265 | 0.74 | MAPT (0.43) | RAB9ANPC1TSHRKMT2AGFER | |
| Ethane SCHEMBL27444853 | 0.73 | TSHR (0.65) | TSHRKMT2AALDH1A1LMNAF2 | |
| Methyl Alcohol SCHEMBL19514313 | 0.73 | TSHR (0.65) | TSHRKMT2AALDH1A1LMNAF2 | |
| Benzene SCHEMBL27793442 | 0.73 | LMNA (0.70) | TSHRKMT2AALDH1A1LMNAF2 | |
| SCHEMBL52413 | 0.73 | LMNA (0.70) | TSHRKMT2AALDH1A1LMNAF2 | |
| Hydrogen Peroxide SCHEMBL27952375 | 0.73 | LMNA (0.70) | TSHRKMT2AALDH1A1LMNAF2 | |
| SCHEMBL27753198 | 0.73 | KMT2A (0.44) | RAB9ANPC1KMT2AGFERALDH1A1 | |
| SCHEMBL11705928 | 0.73 | TDP1 (0.50) | RAB9ANPC1TSHRKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405282-B | Aurora kinase modulators and methods of use | AMGEN INC | 2015-03-25 | — | — | CN | disclosed |
| CN-101405282-A | Aurora kinase modulators and methods of use | AMGEN INC (US) | 2009-04-08 | — | — | CN | disclosed |