Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119640 | 0.91 | TDP1 (0.44) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| Water SCHEMBL30938808 | 0.89 | TDP1 (0.43) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| SCHEMBL8424370 | 0.89 | TDP1 (0.43) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| Ammonia Solution, Strong SCHEMBL6052079 | 0.89 | TDP1 (0.43) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| SCHEMBL10347628 | 0.87 | TDP1 (0.42) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| Ethylene Glycol SCHEMBL4618490 | 0.84 | NPSR1 (0.43) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| Ethylene Glycol SCHEMBL4617853 | 0.84 | NPSR1 (0.43) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| SCHEMBL9763713 | 0.78 | HRH3 (0.36) | SMN1; SMN2HCAR3TDP1SIRT2SIRT1 | |
| SCHEMBL27590497 | 0.77 | CSNK2A1 (0.44) | SMN1; SMN2HCAR3TDP1HSP90AA1ESR2 | |
| Imidazole SCHEMBL27663018 | 0.77 | HCAR3 (0.38) | SMN1; SMN2MAPK1MAP2K4MAPK6MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203518-B | Fluorene derivative, composition containing the same and use thereof | AVENTIS PHARMA SA | 2013-07-24 | — | — | CN | claimed |
| CN-101203518-A | Novel fluorene derivatives, compositions containing same and uses thereof | AVENTIS PHARMA SA (FR) | 2008-06-18 | — | — | CN | claimed |
| CN-101203518-B | Fluorene derivative, composition containing the same and use thereof | AVENTIS PHARMA SA | 2013-07-24 | — | — | CN | disclosed |
| CN-101203518-A | Novel fluorene derivatives, compositions containing same and uses thereof | AVENTIS PHARMA SA (FR) | 2008-06-18 | — | — | CN | disclosed |