Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771518 | 0.94 | NR1H4 (0.50) | NR1H4MAPK14MRGPRX4PTPN11 | |
| SCHEMBL2771218 | 0.89 | NR1H4 (0.51) | NR1H4LTB4RLTB4R2MAPK14MRGPRX4 | |
| SCHEMBL2771508 | 0.89 | NR1H4 (0.51) | NR1H4MRGPRX4 | |
| SCHEMBL2772217 | 0.86 | NR1H4 (0.57) | NR1H4MRGPRX4 | |
| SCHEMBL2773887 | 0.86 | NR1H4 (0.61) | NR1H4MRGPRX4 | |
| SCHEMBL2773673 | 0.85 | NR1H4 (0.47) | NR1H4PPARGPPARDPPARA | |
| SCHEMBL2773436 | 0.84 | NR1H4 (0.55) | NR1H4LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL2770409 | 0.84 | NR1H4 (0.49) | NR1H4PPARGPPARDPPARA | |
| SCHEMBL2772448 | 0.84 | NR1H4 (0.51) | NR1H4LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL2771708 | 0.83 | NR1H4 (0.54) | NR1H4LTB4RLTB4R2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |