Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GFRA3 | O60609 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737386 | 0.86 | DGAT1 (0.51) | DGAT1MGLLCNR2MAPK1HTT | |
| SCHEMBL180771 | 0.86 | DGAT1 (0.52) | DGAT1TBK1PDPK1CNR2GFRA3 | |
| SCHEMBL180787 | 0.84 | DGAT1 (0.64) | DGAT1 | |
| SCHEMBL16546762 | 0.84 | DGAT1 (0.64) | DGAT1 | |
| SCHEMBL13664059 | 0.84 | DGAT1 (0.64) | DGAT1 | |
| SCHEMBL27919808 | 0.81 | DGAT1 (0.57) | DGAT1SYK | |
| SCHEMBL180708 | 0.73 | DGAT1 (0.74) | DGAT1SYK | |
| SCHEMBL180643 | 0.72 | DGAT1 (0.57) | DGAT1CNR2NPC1 | |
| SCHEMBL183567 | 0.71 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL13664073 | 0.70 | DGAT1 (0.70) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103288721-A | (4-(4-[6-(trifluoromethyl-pyridin-3-ylamino)-n-containing-heteroaryl]-phenyl)-cyclohexyl)-acetic acid derivatives and pharmaceutical uses thereof | NOVARTIS AG | 2013-09-11 | — | — | CN | disclosed |
| CN-101415683-B | Novel compounds | NOVARTIS AG | 2013-07-17 | — | — | CN | disclosed |
| CN-103086981-A | New compounds | NOVARTIS AG | 2013-05-08 | — | — | CN | disclosed |
| CN-101415683-A | Novel compounds | NOVARTIS AG (CH) | 2009-04-22 | — | — | CN | disclosed |