Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 14/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770076 | 0.91 | NR1H4 (0.51) | NR1H4SCN9A | |
| SCHEMBL2770754 | 0.88 | NR1H4 (0.34) | NR1H4FFAR1LNPEPPPARD | |
| SCHEMBL2770877 | 0.84 | NR1H4 (0.42) | NR1H4LNPEPPPARD | |
| SCHEMBL2770752 | 0.82 | NR1H4 (0.39) | NR1H4LNPEPPPARD | |
| SCHEMBL2773688 | 0.82 | NR1H4 (0.37) | NR1H4LNPEPPPARD | |
| SCHEMBL2773202 | 0.80 | PPARD (0.36) | NR1H4LNPEPPPARD | |
| SCHEMBL2769767 | 0.79 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL2770864 | 0.78 | NR1H4 (0.39) | NR1H4LNPEPPPARD | |
| SCHEMBL2772951 | 0.77 | NR1H4 (0.37) | NR1H4LNPEPPPARD | |
| SCHEMBL2769790 | 0.76 | NR1H4 (0.41) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | claimed |