Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717231 | 0.84 | HTT (0.42) | KMT2AHTTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL543840 | 0.77 | TUBB4A (0.44) | NR4A1HTTCA1CA2CA9 | |
| SCHEMBL3099735 | 0.73 | SMN1; SMN2 (0.53) | NR4A1KMT2AALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL11846316 | 0.73 | F2 (0.44) | NR4A1KMT2ATDP1 | |
| SCHEMBL11850296 | 0.71 | TUBB4A (0.40) | NR4A1KMT2AHTTCA1CA2 | |
| SCHEMBL11843618 | 0.69 | TDP1 (0.49) | ALDH1A1CYP3A4ALOX15TSHRSMN1; SMN2 | |
| SCHEMBL11849091 | 0.67 | APEX1 (0.67) | NR4A1KMT2AHTTCA1CA2 | |
| SCHEMBL10900544 | 0.67 | NR4A1 (0.52) | NR4A1KMT2ACA1CA2CA9 | |
| SCHEMBL6380044 | 0.66 | TAAR1 (0.46) | KMT2ACA1CA2CA9AKR1B1 | |
| SCHEMBL1272049 | 0.66 | RECQL (0.46) | KMT2AHTTAKR1B1ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273019-A | Novel benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as C-Met inhibitors | AVENTIS PHARMA SA (FR) | 2008-09-24 | — | — | CN | disclosed |