Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411190 | 1.00 | PTGS2 (0.43) | PTGS2NFE2L2CA12CA9GPR27 | |
| SCHEMBL27738946 | 0.88 | STAT3 (0.45) | PTGS2NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL5423015 | 0.88 | STAT3 (0.45) | PTGS2NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL4255157 | 0.86 | MKNK1 (0.49) | PTGS2NFE2L2CYP1B1KMT2AMAPT | |
| SCHEMBL27706028 | 0.86 | MKNK1 (0.49) | PTGS2NFE2L2CYP1B1KMT2AMAPT | |
| SCHEMBL27738949 | 0.86 | CA12 (0.43) | CA12CA9CYP1B1DGAT1ALDH1A1 | |
| SCHEMBL5417556 | 0.86 | CA12 (0.43) | CA12CA9CYP1B1DGAT1ALDH1A1 | |
| SCHEMBL4619299 | 0.85 | ALDH1A1 (0.45) | NFE2L2ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL27738953 | 0.85 | PTGS2 (0.43) | PTGS2NFE2L2GPR27CYP1B1ALDH1A1 | |
| SCHEMBL5415469 | 0.85 | PTGS2 (0.43) | PTGS2NFE2L2GPR27CYP1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268042-A | Styryl sulfonamides, their preparation and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | CN | claimed |
| CN-101268042-A | Styryl sulfonamides, their preparation and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | CN | disclosed |