Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.70 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.69 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | SCD | O00767 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22348631 | 0.84 | NPC1 (0.69) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL8555330 | 0.84 | TP53 (0.70) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL27760115 | 0.84 | NPC1 (0.68) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL7357499 | 0.84 | NPC1 (0.68) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| Water SCHEMBL27805628 | 0.83 | NPC1 (0.67) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL995829 | 0.83 | NPC1 (1.00) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL28461611 | 0.82 | SIRT2 (0.70) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL2072476 | 0.82 | NPC1 (0.65) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| Hydrochloric Acid SCHEMBL27594584 | 0.81 | NPC1 (0.97) | NPC1RAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL13438742 | 0.81 | NPC1 (0.63) | NPC1RAB9AKCNK3KCNK9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101445505-A | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| CN-101445502-A | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| CN-101386618-A | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes | ASTRAZENECA AB (SE) | 2009-03-18 | — | — | CN | disclosed |
| CN-101258150-A | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |