Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 known ✓ | O14649 | 1/20 | 0.76 |
| ▸ | KCNK9 known ✓ | Q9NPC2 | 1/20 | 0.76 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 9/20 | 0.97 |
| ▸ | RAB9A | P51151 | 8/20 | 0.97 |
| ▸ | SCD | O00767 | 1/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | METAP2 | P50579 | 1/20 | 0.67 |
| ▸ | METAP1 | P53582 | 1/20 | 0.67 |
| ▸ | AGER | Q15109 | 1/20 | 0.64 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.63 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995829 | 0.98 | NPC1 (1.00) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL16562033 | 0.92 | SCD (1.00) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL4285954 | 0.91 | NPC1 (0.85) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL4290771 | 0.87 | NPC1 (0.79) | NPC1RAB9ASCDKCNK3KCNK9 | |
| Nitrobenzene SCHEMBL27694792 | 0.86 | NPC1 (0.82) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL11059973 | 0.86 | RAB9A (0.77) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL2628996 | 0.85 | NPC1 (0.76) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL14082184 | 0.84 | NPC1 (0.74) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL4600878 | 0.83 | NPC1 (0.73) | NPC1RAB9ASCDKCNK3KCNK9 | |
| SCHEMBL14096340 | 0.83 | NPC1 (0.73) | NPC1RAB9ASCDKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101492416-B | compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2012-02-22 | — | — | CN | disclosed |
| CN-101704797-A | compounds effecting glucokinase | ASTRAZANECA AB | 2010-05-12 | — | — | CN | disclosed |
| CN-100577163-C | Compounds affecting glucokinase | ASTRAZENECA AB | 2010-01-06 | — | — | CN | disclosed |
| CN-101584691-A | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2009-11-25 | — | — | CN | disclosed |
| CN-101492416-A | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2009-07-29 | — | — | CN | disclosed |
| CN-1568185-A | Compounds affecting glucokinase | ASTRAZENECA AB (SE) | 2005-01-19 | — | — | CN | disclosed |