Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630580 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BFFAR1FFAR4POLB | |
| SCHEMBL27637897 | 0.80 | EPHX2 (0.40) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL27688160 | 0.78 | MEN1 (0.48) | MEN1KMT2AFFAR1FFAR4POLB | |
| SCHEMBL4199804 | 0.76 | MTNR1A (0.42) | MTNR1AMTNR1BKMT2AKDM4EALDH1A1 | |
| SCHEMBL29059884 | 0.76 | CTSS (0.43) | MEN1KMT2AALDH1A1 | |
| SCHEMBL27585416 | 0.76 | MEN1 (0.46) | MEN1KMT2AFFAR1FFAR4KIF11 | |
| SCHEMBL27653420 | 0.75 | MEN1 (0.48) | MEN1KMT2AFFAR1FFAR4KIF11 | |
| SCHEMBL27903191 | 0.74 | MEN1 (0.47) | MEN1KMT2AFFAR1FFAR4KIF11 | |
| SCHEMBL3694006 | 0.74 | MTNR1A (0.39) | MTNR1AMTNR1BHPGDHDAC8MIF | |
| SCHEMBL2395059 | 0.73 | POLB (0.43) | MTNR1AMTNR1BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437796-A | Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |