Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770449 | 0.85 | ACLY (0.44) | POLBMEN1KMT2AMAPTCNR2 | |
| SCHEMBL2770023 | 0.80 | HCRTR1 (0.42) | POLBMAPTCNR2RXFP1NPC1 | |
| SCHEMBL2770132 | 0.73 | ABCB1 (0.44) | PTGDR2GAAPTGDRFLT1FLT4 | |
| SCHEMBL2769434 | 0.72 | PTGDR2 (0.41) | PTGDR2PTGDRCNR1PTGS2KDM4E | |
| SCHEMBL2769429 | 0.72 | EGFR (0.43) | MEN1KMT2AMAPTPTGDR2CNR2 | |
| SCHEMBL4636277 | 0.71 | HCRTR1 (0.43) | POLBMEN1KMT2AMAPTPTGDR2 | |
| SCHEMBL2771980 | 0.69 | GAA (0.51) | POLBMEN1KMT2AMAPTRXFP1 | |
| SCHEMBL2770435 | 0.65 | ALDH1A1 (0.40) | MEN1KMT2APTGDR2GAAPTGDR | |
| SCHEMBL15207967 | 0.63 | PTGDR2 (0.80) | PTGDR2 | |
| SCHEMBL4635636 | 0.63 | HCRTR1 (0.52) | POLBMEN1KMT2AMAPTPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910357-B1 | INDOLI ZINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | ARGENTA DISCOVERY LTD (GB) | 2010-04-14 | — | — | EP | disclosed |