Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.56 |
| ▸ | RAF1 | P04049 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740910 | 0.89 | LCK (0.56) | BRAFRAF1LCKMAPK14KIT | |
| SCHEMBL27740922 | 0.88 | BRAF (0.58) | BRAFRAF1LCKMAPK14KIT | |
| SCHEMBL27740911 | 0.87 | BTK (0.57) | BRAFRAF1LCKMAPK14KIT | |
| SCHEMBL3824167 | 0.87 | KDR (0.65) | BRAFLCKMAPK14KITSRC | |
| SCHEMBL3829573 | 0.77 | KDR (0.68) | BRAFLCKMAPK14KITSRC | |
| SCHEMBL3824997 | 0.77 | KDR (0.67) | BRAFLCKMAPK14KITSRC | |
| SCHEMBL13198172 | 0.77 | BRAF (0.74) | BRAFRAF1LCKMAPK14KIT | |
| SCHEMBL3824874 | 0.76 | KDR (0.65) | BRAFLCKMAPK14KITSRC | |
| SCHEMBL374545 | 0.75 | LCK (0.68) | BRAFRAF1LCKMAPK14KIT | |
| SCHEMBL3823481 | 0.74 | KDR (0.64) | BRAFLCKMAPK14KITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | claimed |