Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 8/20 | 0.56 |
| ▸ | BRAF | P15056 | 7/20 | 0.56 |
| ▸ | LCK | P06239 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740910 | 0.87 | LCK (0.56) | BTKRAF1BRAFLCKSRC | |
| SCHEMBL27740909 | 0.87 | BRAF (0.56) | BTKRAF1BRAFLCKSRC | |
| SCHEMBL3823481 | 0.87 | KDR (0.64) | BTKBRAFLCKSRCABL1 | |
| SCHEMBL27740922 | 0.86 | BRAF (0.58) | BTKRAF1BRAFLCKSRC | |
| SCHEMBL3824106 | 0.82 | KDR (0.60) | BTKBRAFLCKSRCMAPK14 | |
| SCHEMBL3823342 | 0.82 | LCK (0.65) | RAF1BRAFLCKSRCMAPK14 | |
| SCHEMBL3824880 | 0.80 | KDR (0.74) | BTKBRAFLCKSRCMAPK14 | |
| SCHEMBL3593395 | 0.80 | KDR (0.59) | BTKRAF1BRAFLCKSRC | |
| SCHEMBL3589391 | 0.79 | KDR (0.59) | BTKRAF1BRAFLCKSRC | |
| SCHEMBL27720381 | 0.77 | BTK (0.83) | BTKBRAFLCKSRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | claimed |