Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.58 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | LCK | P06239 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740909 | 0.88 | BRAF (0.56) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL27740910 | 0.88 | LCK (0.56) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL27740911 | 0.86 | BTK (0.57) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL3826288 | 0.86 | KDR (0.68) | BRAFMAPK14LCKKITABL1 | |
| SCHEMBL13198172 | 0.79 | BRAF (0.74) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL3823531 | 0.78 | KDR (0.79) | BRAFMAPK14LCKKITSRC | |
| SCHEMBL3824997 | 0.77 | KDR (0.67) | BRAFMAPK14LCKKITABL1 | |
| SCHEMBL13220190 | 0.77 | LCK (0.76) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL23362271 | 0.77 | RAF1 (0.59) | BRAFRAF1MAPK14LCKKIT | |
| SCHEMBL3828363 | 0.77 | KDR (0.66) | BRAFMAPK14LCKKITABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | claimed |