Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10274471 | 0.90 | AURKA (0.47) | KDM4EPTGER1AURKARPS6KB1LMNA | |
| SCHEMBL1234211 | 0.85 | KDM4E (0.46) | KDM4EPTGER1AURKARPS6KB1CNR1 | |
| SCHEMBL28802830 | 0.83 | HCAR3 (0.44) | PTGER1HCAR3CNR1CNR2SMPD1 | |
| SCHEMBL1232307 | 0.83 | KDM4E (0.44) | KDM4ECNR1CNR2 | |
| SCHEMBL2360638 | 0.82 | AURKA (0.60) | KDM4EPTGER1AURKARPS6KB1LMNA | |
| SCHEMBL28287819 | 0.82 | HCAR3 (0.43) | HCAR3CNR1CNR2SMPD1HCAR2 | |
| SCHEMBL20461114 | 0.82 | CNR1 (0.45) | PTGER1HCAR3CNR1CNR2SMPD1 | |
| SCHEMBL17489117 | 0.80 | LMNA (0.47) | PTGER1AURKARPS6KB1LMNAPTGER3 | |
| SCHEMBL13659680 | 0.79 | PTGER1 (0.44) | KDM4EPTGER1AURKARPS6KB1LMNA | |
| SCHEMBL29834790 | 0.78 | CNR2 (0.46) | KDM4ECNR1CNR2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | claimed |
| CN-101421262-A | Compounds and compositions as protein kinase inhibitors | IRM LLC (VG) | 2009-04-29 | — | — | CN | disclosed |