Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.78 |
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | PRKX | P51817 | 3/20 | 0.55 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.55 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.54 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521962 | 1.00 | ROCK1 (0.78) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL4522532 | 0.88 | ROCK2 (0.78) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL4532179 | 0.88 | ROCK2 (1.00) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL16227543 | 0.88 | ROCK2 (1.00) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL15141125 | 0.88 | ROCK2 (1.00) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL27723706 | 0.87 | ROCK2 (0.77) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL4525577 | 0.87 | ROCK2 (0.77) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL20397737 | 0.83 | POLB (0.59) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL4512609 | 0.82 | ROCK2 (0.73) | ROCK1ROCK2PRKACAPRKXPRKG1 | |
| SCHEMBL27744405 | 0.82 | ROCK2 (0.73) | ROCK1ROCK2PRKACAPRKXPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101253152-A | Amide derivatives as ROCK inhibitors | ASTELLAS PHARMA INC (JP) | 2008-08-27 | — | — | CN | disclosed |