Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | PRKX | P51817 | 3/20 | 0.55 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27723706 | 1.00 | ROCK2 (0.77) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL27744447 | 0.87 | ROCK1 (0.78) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL4521962 | 0.87 | ROCK1 (0.78) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL15141125 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL4532179 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL16227543 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL4534345 | 0.82 | ROCK2 (0.72) | ROCK2ROCK1CLK4GSK3BNAMPT | |
| Hydrochloric Acid SCHEMBL31651005 | 0.81 | ROCK2 (0.70) | ROCK2ROCK1CLK4GSK3BNAMPT | |
| SCHEMBL4513647 | 0.81 | ROCK1 (0.71) | ROCK2ROCK1CLK4GSK3BPRKACA | |
| SCHEMBL27744442 | 0.81 | ROCK1 (0.71) | ROCK2ROCK1CLK4GSK3BPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| CN-101253152-A | Amide derivatives as ROCK inhibitors | ASTELLAS PHARMA INC (JP) | 2008-08-27 | — | — | CN | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885CLK4 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.