Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27744893 | 0.95 | MAPK14 (0.63) | MAPK14LMNACFD | |
| SCHEMBL27765823 | 0.92 | MAPK14 (0.80) | MAPK14LMNAGAAMAPTKDM6B | |
| SCHEMBL27765847 | 0.92 | MAPK14 (0.59) | MAPK14LMNACFD | |
| SCHEMBL27765846 | 0.90 | MAPK14 (0.70) | MAPK14CFDALDH1A1HPGDHSD17B10 | |
| SCHEMBL27834750 | 0.89 | MAPK14 (0.59) | MAPK14LMNACFDTTK | |
| SCHEMBL4334980 | 0.89 | MAPK14 (0.88) | MAPK14LMNAMAPTKDM6BKDM4D | |
| SCHEMBL4329415 | 0.88 | MAPK14 (0.71) | MAPK14LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4333469 | 0.88 | MAPK14 (0.86) | MAPK14LMNAKDM6BKDM4DKDM4C | |
| SCHEMBL27765813 | 0.86 | MAPK14 (0.73) | MAPK14LMNA | |
| SCHEMBL27744896 | 0.86 | MAPK14 (0.68) | MAPK14LMNAKDM6BKDM4DKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472921-A | Pyridylisoxazole derivative | ASKA PHARM CO LTD (JP) | 2009-07-01 | — | — | CN | claimed |
| CN-101472921-B | Pyridylisoxazole derivative | ASKA PHARM CO LTD | 2012-10-10 | — | — | CN | disclosed |
| CN-101472921-A | Pyridylisoxazole derivative | ASKA PHARM CO LTD (JP) | 2009-07-01 | — | — | CN | disclosed |