Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | GSK3A | P49840 | 4/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15795562 | 0.80 | AXL (0.46) | GSK3BGSK3AIGF1RMEN1KMT2A | |
| SCHEMBL5514466 | 0.79 | GSK3B (0.55) | GSK3BGSK3AMEN1KMT2AATM | |
| SCHEMBL385263 | 0.77 | GSK3A (0.70) | ULK1GSK3BGSK3ACDK2AXL | |
| SCHEMBL385264 | 0.77 | GSK3A (0.70) | ULK1GSK3BGSK3ACDK2AXL | |
| SCHEMBL17544767 | 0.76 | GSK3B (0.64) | ULK1GSK3BGSK3AMEN1KMT2A | |
| SCHEMBL25250460 | 0.76 | GSK3B (0.67) | GSK3BGSK3AMEN1KMT2AATM | |
| SCHEMBL31116668 | 0.75 | GSK3B (0.43) | ULK1GSK3BGSK3AIGF1RMEN1 | |
| SCHEMBL14060018 | 0.74 | GSK3B (0.57) | GSK3BGSK3AIGF1RCDK5CDK2 | |
| SCHEMBL14059898 | 0.74 | GSK3B (0.57) | GSK3BGSK3AIGF1RCDK5CDK2 | |
| SCHEMBL5921620 | 0.74 | PTK2 (0.50) | GSK3BGSK3AIGF1RCDK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101478972-A | Haloaryl substituted aminopurines, compositions thereof, and methods of using same in therapy | SIGNAL PHARM LLC (US) | 2009-07-08 | — | — | CN | disclosed |