Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | PLK1 | P53350 | 10/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5921480 | 0.87 | PTK2 (0.52) | PTK2PLK1AURKBAURKALRRK2 | |
| SCHEMBL1467078 | 0.77 | LRRK2 (0.51) | PTK2LRRK2ALK | |
| SCHEMBL12745485 | 0.77 | LRRK2 (0.51) | PTK2LRRK2ALK | |
| SCHEMBL12745482 | 0.77 | LRRK2 (0.51) | PTK2LRRK2 | |
| SCHEMBL1466613 | 0.77 | LRRK2 (0.51) | PTK2LRRK2 | |
| SCHEMBL29714355 | 0.75 | PLK1 (0.68) | PLK1ALKJAK2SRC | |
| SCHEMBL5921220 | 0.75 | CDK4 (0.53) | PTK2PLK1MAPK1MAPK9PLK3 | |
| SCHEMBL1163979 | 0.74 | PTK2 (0.54) | PTK2 | |
| SCHEMBL27745500 | 0.74 | ULK1 (0.57) | PLK1AURKAAXLGSK3AGSK3B | |
| SCHEMBL16995419 | 0.73 | PTK2 (0.53) | PTK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060047118-A1 | New pteridinones as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047118-A1 | New pteridinones as PLK inhibitors | PLK2, PLK4, PLK3 | PTK2 212/4885PLK1 22/4885AURKB 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.