Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.50 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL8331400 | 0.97 | GPR84 (0.62) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL8550409 | 0.97 | GPR84 (0.62) | TSHRGPR84FFAR1PPARDMAPT | |
| Decane SCHEMBL27602602 | 0.97 | GPR84 (0.62) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL27345329 | 0.97 | GPR84 (0.62) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL27635614 | 0.95 | GPR84 (0.60) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL27361900 | 0.95 | GPR84 (0.60) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL6120604 | 0.88 | TSHR (0.59) | TSHRGPR84FFAR1PPARDMAPT | |
| Cetostearyl Alcohol SCHEMBL9697588 | 0.88 | TSHR (0.59) | TSHRGPR84FFAR1PPARDMAPT | |
| Tetrabuthylammonium SCHEMBL5874524 | 0.88 | SLC22A1 (0.55) | TSHRGPR84FFAR1PPARDMAPT | |
| Cadaverine Tartrate SCHEMBL10797841 | 0.88 | GPR84 (0.59) | TSHRGPR84FFAR1PPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102741239-B | Bicyclic compounds as alpha4beta2 nicotinic acetylcholine receptor ligands | SUVEN LIFE SCIENCES LTD | 2015-06-24 | — | — | CN | claimed |
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | claimed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | claimed |
| CN-102741239-A | Bicyclic compounds as alpha4beta2 nicotinic acetylcholine receptor ligands | SUVEN LIFE SCIENCES LTD | 2012-10-17 | — | — | CN | claimed |
| CN-101528221-A | Use of azabicyclohexane derivatives | GLAXO GROUP LTD (GB) | 2009-09-09 | — | — | CN | claimed |
| CN-102741239-B | Bicyclic compounds as alpha4beta2 nicotinic acetylcholine receptor ligands | SUVEN LIFE SCIENCES LTD | 2015-06-24 | — | — | CN | disclosed |
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | disclosed |
| CN-101528221-B | Use of azabicyclohexane derivatives | GLAXO GROUP LTD | 2013-05-08 | — | — | CN | disclosed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-102741239-A | Bicyclic compounds as alpha4beta2 nicotinic acetylcholine receptor ligands | SUVEN LIFE SCIENCES LTD | 2012-10-17 | — | — | CN | disclosed |
| CN-101291669-B | Use of azabicyclo hexane derivatives | GLAXO GROUP LTD | 2012-09-26 | — | — | CN | disclosed |
| CN-101528221-A | Use of azabicyclohexane derivatives | GLAXO GROUP LTD (GB) | 2009-09-09 | — | — | CN | disclosed |
| CN-101291669-A | Use of azabicyclo hexane derivatives | GLAXO GROUP LTD (GB) | 2008-10-22 | — | — | CN | disclosed |