Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADM2 | Q7Z4H4 | 6/20 | 0.40 |
| ▸ | CALCRL | Q16602 | 14/20 | 0.38 |
| ▸ | CALCB | P10092 | 5/20 | 0.38 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2097358 | 0.81 | CALCA (0.39) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL15387275 | 0.77 | CALCA (0.37) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL18274538 | 0.73 | CALCRL (0.39) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL837503 | 0.73 | ADM2 (0.49) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL837518 | 0.72 | CALCRL (0.45) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL3706135 | 0.70 | CALCRL (0.56) | ADM2CALCRLRAMP1 | |
| SCHEMBL2895570 | 0.68 | CALCA (0.38) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL10246001 | 0.68 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 | |
| SCHEMBL16235885 | 0.67 | CALCA (0.46) | ADM2CALCRLCALCB | |
| SCHEMBL1815456 | 0.67 | CALCRL (0.51) | ADM2CALCRLCALCBRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146572-A1 | BICYCLIC ANILIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008130512-A1 | BICYCLIC ANILIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | disclosed |