Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 18/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60270 | 0.86 | ACVRL1 (0.50) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL59787 | 0.81 | ACVRL1 (0.49) | ACVRL1 | |
| SCHEMBL28781326 | 0.80 | ACVRL1 (0.38) | ACVRL1 | |
| SCHEMBL65573 | 0.80 | ACVRL1 (0.38) | ACVRL1 | |
| SCHEMBL19377764 | 0.79 | ACVRL1 (0.64) | ACVRL1AXLMERTK | |
| SCHEMBL59573 | 0.78 | ACVRL1 (0.65) | ACVRL1 | |
| SCHEMBL64684 | 0.72 | ACVRL1 (0.51) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL27768106 | 0.71 | ACVRL1 (0.61) | ACVRL1AXLMERTK | |
| SCHEMBL25178820 | 0.70 | ACVRL1 (0.56) | ACVRL1AXLMERTKTYRO3 | |
| SCHEMBL27747182 | 0.70 | ACVRL1 (0.65) | ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |