Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 18/20 | 0.61 |
| ▸ | MERTK | Q12866 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59518 | 0.86 | ACVRL1 (0.55) | ACVRL1MERTK | |
| SCHEMBL59418 | 0.83 | ACVRL1 (0.82) | ACVRL1MERTK | |
| SCHEMBL14888176 | 0.82 | ACVRL1 (0.46) | ACVRL1MERTK | |
| SCHEMBL5031587 | 0.81 | ACVRL1 (0.47) | ACVRL1MERTKAXL | |
| SCHEMBL59483 | 0.79 | ACVRL1 (0.76) | ACVRL1MERTK | |
| SCHEMBL56767 | 0.79 | ACVRL1 (0.58) | ACVRL1MERTK | |
| SCHEMBL5132716 | 0.78 | IKBKE (0.52) | ACVRL1AXL | |
| SCHEMBL59573 | 0.78 | ACVRL1 (0.65) | ACVRL1 | |
| SCHEMBL19377767 | 0.78 | ACVRL1 (0.58) | ACVRL1MERTKAXL | |
| SCHEMBL15211727 | 0.77 | FGFR1 (0.50) | ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |