Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046883 | 0.88 | GPR119 (0.39) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL5049760 | 0.85 | GPR119 (0.43) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL5264798 | 0.81 | GPR119 (0.41) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL388438 | 0.80 | GPR119 (0.66) | GPR119 | |
| SCHEMBL5048550 | 0.79 | GPR119 (0.49) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL4719555 | 0.78 | GPR119 (0.52) | GPR119FLT3CDK2CDK6DGAT1 | |
| SCHEMBL4269127 | 0.78 | CSNK2A2 (0.43) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL5049360 | 0.77 | GPR119 (0.37) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL5046882 | 0.76 | GPR119 (0.46) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL3672449 | 0.74 | GPR119 (0.67) | GPR119CDK2CDK6CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |